In studies of mice and men, researcher found high fat level disrupted two key proteins turn genes on and off. The two key proteins activate a pancreatic enzyme that in healthy people prevents diabetes developing.
When proteins stop working, the enzyme is shut down. This upsets the ability of insulin-secreting beta cells in the pancreas to monitor blood sugar levels. Without this sensing mechanism, blood sugar cannot be regulated properly. Study leader Dr Jamey Marth, from the Stanford-Burnham Medical Research Institute in the US.
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